Reinventing Radiobiology in the Light of FLASH Radiotherapy

Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting treatment modality that holds the promise of expanding therapeutic index for nearly any cancer. At heart this exciting technology comes capability to ameliorate major normal tissue complications without compromising efficacy tumor killing. This combination benefits has now been termed effect and relies on an in vivo validation rigorously demonstrate absence toxicity. The occurs when overall irradiation time extremely short (<500 ms), review we attempt understand how FLASH-RT can kill tumors but spare tissues—likely single most pressing question confronting field today.